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A groundbreaking study found that trigonelline, found in coffee and fenugreek, boosts muscle health in aging by improving NAD+ levels and mitochondrial function, offering new strategies for healthy aging and disease prevention.
A research consortium led by Nestlé Research in Switzerland and the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) made a recent discovery that the natural molecule trigonelline present in coffee, fenugreek, and also in the human body, can help to improve muscle health and function.
In an international collaboration among the University of Southampton, University of Melbourne, University of Tehran, University of South Alabama, University of Toyama, and University of Copenhagen, the work builds on a previous collaborative study that described novel mechanisms of human sarcopenia.
Sarcopenia is a condition where cellular changes that happen during aging gradually weaken the muscles in the body and lead to accelerated loss of muscle mass, strength and reduced physical independence.
One important problem during sarcopenia is that the cellular cofactor NAD+ declines during aging, while mitochondria, the energy powerhouses in our cells, produce less energy. The study team discovered that levels of trigonelline were lower in older people with sarcopenia. Providing this molecule in pre-clinical models resulted in increased levels of NAD+, increased mitochondrial activity, and contributed to the maintenance of muscle function during aging.
Nutritional Approaches to Combat Aging
NAD+ levels can be enhanced with different dietary precursors like the essential amino acid L-tryptophan (L-Trp), and vitamin B3 forms such as nicotinic acid (NA), nicotinamide (NAM), nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).
Assistant Professor Vincenzo Sorrentino from the Healthy Longevity Translational Research Programme at NUS Medicine added, “Our findings expand the current understanding of NAD+ metabolism with the discovery of trigonelline as a novel NAD+ precursor and increase the potential of establishing interventions with NAD+-producing vitamins for both healthy longevity and age-associated diseases applications.”
Nutrition and physical activity are important lifestyle recommendations to maintain healthy muscles during aging. “We were excited to discover through collaborative research that a natural molecule from food cross-talks with cellular hallmarks of aging. The benefits of trigonelline on cellular metabolism and muscle health during aging opens promising translational applications,” said Jerome Feige, Head of the Physical Health department at Nestlé Research.
Reference: “Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia” by Mathieu Membrez, Eugenia Migliavacca, Stefan Christen, Keisuke Yaku, Jennifer Trieu, Alaina K. Lee, Francesco Morandini, Maria Pilar Giner, Jade Stiner, Mikhail V. Makarov, Emma S. Garratt, Maria F. Vasiloglou, Lucie Chanvillard, Emilie Dalbram, Amy M. Ehrlich, José Luis Sanchez-Garcia, Carles Canto, Leonidas G. Karagounis, Jonas T. Treebak, Marie E. Migaud, Ramin Heshmat, Farideh Razi, Neerja Karnani, Afshin Ostovar, Farshad Farzadfar, Stacey K. H. Tay, Matthew J. Sanders, Karen A. Lillycrop, Keith M. Godfrey, Takashi Nakagawa, Sofia Moco, René Koopman, Gordon S. Lynch, Vincenzo Sorrentino and Jerome N. Feige, 19 March 2024, Nature Metabolism.
DOI: 10.1038/s42255-024-00997-x
